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Upstate Biotechnology Inc top fop flash test
Top Fop Flash Test, supplied by Upstate Biotechnology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Related Articles

Activity Assay:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Ligation:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Transfection:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Binding Assay:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Luciferase:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Plasmid Preparation:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Negative Control:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Construct:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Mutagenesis:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Control:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Activation Assay:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Reporter Assay:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.

Western Blot:

Article Title: Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
Article Snippet: To evaluate β -catenin/TCF-4 transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and FOP-FLASH (Upstate Biotechnology, Lake Placid, NY, USA).

Article Title: Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
Article Snippet: To assess the transcriptional activity of β-catenin following PMN or Ab-mediated ligation of ICAM-1, SW480 colonic epithelial cells were seeded in 48 well tissue culture plates (60,000 cells/well) and transiently transfected with a β-catenin reporter containing 3 TCF/LEF binding sites upstream of the luciferase reporter (TOP-Flash plasmid) or a negative control, FOP-Flash, which contains 3 TCF/LEF mutated binding sites upstream of the luciferase reporter (Upstate Biotechnology, Inc., Lake Placid, NY).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo.
Article Snippet: Of note, XGli1 did not significantly reduce Xptβ-catenin-induced Wnt pathway activation in XSufu-morphants (Fig. 8E).We did not observe activation of the 8x3′mGli-BS luc reporter in which the Gli binding sites are mutated (Sasaki et al., 1997) nor activation of FOP-flash (Upstate Biotechnology), an altered TOP-flash construct in which the Tcf binding sites are inactivated by point mutations (Fig. 8B–E).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: Luciferase Reporter Assay To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: Synergism between Wnt3a and Heparin Enhances Osteogenesis via a Phosphoinositide 3-Kinase/Akt/RUNX2 Pathway
Article Snippet: To determine LEF1/TCF transcription activity, 0.4 μg of the reporter plasmids TOP-FLASH or FOP-FLASH (Upstate Biotechnology) were transfected into 40,000 cells with Lipofectamine 2000 (Invitrogen).

Article Title: The β-catenin Axis Integrates Multiple Signals Downstream From RET/PTC and Leads to Cell Proliferation
Article Snippet: Reporter assay To evaluate the TCF/LEF transcriptional activity, we used a pair of luciferase reporter constructs, TOP-FLASH and the negative control FOP-FLASH (Upstate Biotechnology).

Article Title: Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.
Article Snippet: Prior to gastrulation, the Wnt signaling pathway through stabilized b-catenin enhances the differentiation of mouse ES cell into cardiomyocytes.. We have recently shown that cardiomyocyte differentiation is enhanced by eosinophil cationic protein (ECP) through accelerated expression of marker genes of early cardiac differentiation.. Furthermore, ECP enhanced the expression of Wnt3a in P19CL6 cells which were stimulated to differentiate into cardiomyocytes by DMSO.



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